GraFutureTM
Graphene Oxide
Support Film

To overcome the bottleneck in cryo-EM sample preparation, Shuimu developed a series of graphene coated grids - GraFutureTM, using them to achieve a better reproducibility and efficiency of cryo-EM sample preparation.

Cryo-EM sample preparation using traditional support grids has certain problems for specific cases.

- Air-water interface absorption
- Badly preferred orientation
- Sample concentration threshold (>1μM)
- Significant background noise
- Difficulty of reconstructing “small” macromolecules

Shuimu introduces a series of performance-driven graphene grid products - GraFutureTM, to overcome the bottleneck.

GraFuture TM GO

Graphene Oxide Support Film TEM Gird

GraFuture TM RGO

Reduced Graphene Oxide Support Film TEM Gird

GraFuture TM SCG

Single-Crystalline Graphene Support Film TEM Grid

GraFutureTM grids could be used with the following advantages:

-Partial protection from the air-water interface
-More balanced particle orientation distribution
-Low sample concentration (≈100 nM)
-Low background noise
-Successfully solved the structure of sub-100 kDa macromolecules at 2.8 Å resolution
-Providing hexagonal lattice signal, enabling assessment of the cryo-EM image quality & motion correction

GO/RGO SPECS

Ultra-Thin
GO/RGO

TYPE

≤ 5 layers

THICKNESS

≥ 70%

COVERAGE

PERFORMANCES

CASE STUDIES

GO

Cell. 2022 Feb 17;185(4):630-640.e10.

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

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RGO

Nature. 2022 Jul;607(7918):399-406.

Structural insights into dsRNA processing by Drosophila Dicer-2-Lo- qs-PD

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Nature. 2022 Apr;604(7905):377-383.

Structure deformation and curvature sensing of PIEZO1 in lipid mem- branes

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Science. 2021 Jan 8;371(6525):eabe8863.

Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2

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