GraFutureTM
Graphene Oxide
Support Film

To overcome the bottleneck in cryo-EM sample preparation, Shuimu developed a series of graphene coated grids - GraFutureTM, using them to achieve a better reproducibility and efficiency of cryo-EM sample preparation.

Cryo-EM sample preparation using traditional support grids has certain problems for specific cases.

- Air-water interface absorption
- Badly preferred orientation
- Sample concentration threshold (>1μM)
- Significant background noise
- Difficulty of reconstructing “small” macromolecules

Shuimu introduces a series of performance-driven graphene grid products - GraFutureTM, to overcome the bottleneck.

GraFuture TM GO

Graphene Oxide Support Film TEM Gird

GraFuture TM RGO

Reduced Graphene Oxide Support Film TEM Gird

GraFutureTM grids could be used with the following advantages:

-Partial protection from the air-water interface
-More balanced particle orientation distribution
-Low sample concentration (≈100 nM)
-Low background noise
-Successfully solved the structure of sub-100 kDa macromolecules at 2.8 Å resolution
-Providing hexagonal lattice signal, enabling assessment of the cryo-EM image quality & motion correction

GO/RGO SPECS

Ultra-Thin
GO/RGO

TYPE

≤ 5 layers

THICKNESS

≥ 70%

COVERAGE

PERFORMANCES

CASE STUDIES

GO

Cell. 2022 Feb 17;185(4):630-640.e10.

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2

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RGO

Nature. 2022 Jul;607(7918):399-406.

Structural insights into dsRNA processing by Drosophila Dicer-2-Lo- qs-PD

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Nature. 2022 Apr;604(7905):377-383.

Structure deformation and curvature sensing of PIEZO1 in lipid mem- branes

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Science. 2021 Jan 8;371(6525):eabe8863.

Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2

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