Preprint:
Cryo-EM complex structure of
active GPR75 with a nanobody

Shuimu has just published the world's first cryo-EM structure of the promising anti-obesity target GPR75.

  

A Powerful Cryo-EM
Platform for Efficient
Drug Discovery

Realizing fast & economical lead discovery requires accurate structures of biomolecules. Shuimu cryo-EM platform is built with top-notch structure determination capability to meet your needs.

  

Preprint:
Cryo-EM
structure of DNA
polymerase θ helicase
domain in complex
with inhibitor novobiocin

  

ABOUT US

Advanced Cryo-EM Center for Rational Drug Design.

We are a team of experienced scientists from structural biology, protein science and computational chemistry fields, equipped with the best cryo-EMs and computing hardwares. Our cryo-EM platform is built to help you achieve rational drug design targeting proteins resistant to X-ray crystallography, such as membrane proteins.

  
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8+

Superior 300kV Cryo-EM

200+

Single Particle Projects

150+

Structures better than 3.5Å

1.5Å

Highest Resolution Obtained

51kDa

Smallest Protein Analyzed

NUMBERS

Rapidly
Growing.

We are continously pushing the boundaries of cryo-EM structure determination.

SERVICES

One-Stop Solutions for
Cryo-EM-Powered Drug Discovery.

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Cryo-EM SPA

Determine structures of biomacro­molecules frozen in vitreous ice at their near-native states.

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MicroED

Acquire high-resolution structures from very thin micro and nano­crystals of organic compouds.

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Protein Production

Produce proteins for high-resolution structures, from macromolecules to diverse membrane proteins.

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CADD

Use algorithms trained by our unique structural biology database to boost your drug discovery.

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GraFuture TM

A series of self-innovated graphene grid products for better reproducibility and efficiency of cryo-EM sample preparation

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CASES

Structures Solved by Shuimu

Our platform has delivered high-quality cryo-EM and microED structures to over 200 clients since 2017.

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PARTNERS & CLIENTS

Together We Made
Great Discoveries.

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