300kV cryo-EM Instrument Booking and Data Collection

The Shuimu BioSciences Cryo-EM Center boasts eight state-of-the-art 300kV cryoEM and comprehensive gear. We offer global clients easy booking and high-throughput data collection focusing on quality expedites structure analysis.

Advantages of
Our Services

24/7 Service

Prioritize Customer Needs

AI Driven Platform

Daily Platform Maintenance

300kv Krios cryo-EM
Single Particle Projects
Structures better than 3.5Å
Highest Resolution Obtained
Smallest Protein analyzed

Business Process

Free cryo-sample freezing service available

Note: Instrument booking is done on a daily basis (from 9:00 AM on day T to 9:00 AM on day T+1)

Project consultation and communication

Instrument booking

Contract and payment

Instrument Scheduling

Grid submission and delivery

Data collection

Data delivery

Hardware Configuration of Cryo-EM Center

Shuimu owns the world's largest and most advanced biopolymer imaging equipment, featuring top-tier hardware and software for superior imaging quality.

Daily inspections and maintenance ensure optimal performance, maintaining each microscope's availability at over 330 days per year. The annual trouble-free operation rate exceeds 97%.
Falcon 4 camera
C-CFEG (cold field-emission electron gun) Electron Source
Selectris X imaging filter
Pre-tilt Sample Holder (±70°)
Configured software for EPU, Tomography & Velox
AFIS (aberration-free image shift)
FFI (fringe free imaging)
Maximum Operational Efficiency: 8000 Pics / Day

A glance of our CryoEM Platform

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Wang H, Lv S, Stroebel D, et al. Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors[J]. Neuron, 2021.
Xia R, Wang N, Xu Z, et al. Cryo-EM structure of the human histamine H 1 receptor/G q complex[J]. Nature communications, 2021, 12(1): 1-9.
Yin Y L, Ye C, Zhou F, et al. Molecular basis for kinin selectivity and activation of the human bradykinin receptors [J]. Nature Structural & Molecular Biology, 2021, 28: 755-761.
Ma X, Zou F, Yu F, et al. Nanoparticle vaccines based on the receptor binding domain (RBD) and heptad repeat (HR) of SARS-CoV-2 elicit robust protective immune responses[J]. Immunity, 2020, 53(6): 1315-1330. e9.
Du S, Liu P, Zhang Z, et al. Structures of SARS-CoV-2 B. 1.351 neutralizing antibodies provide insights into cocktail design against concerning variants[J]. Cell Research, 2021: 1-4.
Nie J, Xie J, Liu S, et al. Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants[J]. Cell Discovery, 2021, 7(1): 1-11.
Song D, Wang W, Dong C, et al. Structure and function analysis of a potent human neutralizing antibody CA521 FALA against SARS-CoV-2[J]. Communications biology, 2021, 4(1): 1-11.
Ma J, Su D, Sun Y, et al. Cryo-electron Microscopy Structure of S-Trimer, a Subunit Vaccine Candidate for COVID-19[J]. Journal of Virology, 2021, 95(11): e00194-21.

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To inquire about our services, simply fill out this form and we'll be in touch.

See Unseeable.
Drug Undruggable.

Founded in 2017, Shuimu BioSciences aims to bring the power of cryo-EM to innovative therapeutics developers.


1 Broadway 5th floor, Cambridge, MA 02142, United States+1 (650) 680 9298


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