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Shuimu Technology

We've developed unique tookits to excel in cryo-EM structure determination.

GraFuture™ Graphene Oxide Support Film

To overcome the bottleneck in cryo-EM sample preparation, Shuimu developed a series of graphene coated grids - GraFuture™, using them to achieve a better reproducibility and efficiency of cryo-EM sample preparation.
CryoEM at Shuimu CryoEM Center

challenges

Challenges in Traditional Cryo-EM Sample Preparation

Cryo-EM sample preparation using traditional support grids presents
Air-water interface absorption
Badly preferred orientation
Sample concentration threshold (>1μM)
Significant background noise
Difficulty of reconstructing “small” macromolecules

GraFuture™ Grid Products

Unlock Efficiency and Precision with GraFuture™ Grids

Shuimu's GraFuture CryoEM GO & RGO Grid solving preferential orientation issues
GraFuture™ GO from Shuimu Biosciences

GraFuture™ GO

Graphene Oxide Support Film TEM Gird
GraFuture™ RGO from Shuimu Biosciences

GraFuture™ RGO

Reduced Graphene Oxide Support Film TEM Gird

Why choose us?

GraFuture™ Grids Advantages

GraFuture™ grids could be used with the following advantages:
GraFuture™ Grids Advantages

specifications

Graphene Oxide
Reduced Graphene Oxide Specs

GraFuture™ From Shuimu Biosciences≤ 5 layersthickness
GraFuture™ RGO go/rgotype
≥ 70 %COVERAGE

performance highlights

Witness Excellence with GraFuture™

GraFuture™ GO from Shuimu BiosciencesGraFuture™ RGO from Shuimu BiosciencesGraFuture™ RGO from Shuimu Biosciences

case studies

GO & RGO

Cell. 2022 Feb 17;185(4):630-640.e10.

GO

Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2Cell. 2022 Feb 17;185(4):630-640.e10.
Read More
Nature. 2022 Jul;607(7918):399-406.

RGO

Structural insights into dsRNA processing by Drosophila Dicer-2-Lo- qs-PDNature. 2022 Jul;607(7918):399-406.
Read More
Nature. 2022 Apr;604(7905):377-383.

RGO

Structure deformation and curvature sensing of PIEZO1 in lipid mem- branesNature. 2022 Apr;604(7905):377-383.
Read More
Science. 2021 Jan 8;371(6525):eabe8863.

RGO

Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2Science. 2021 Jan 8;371(6525):eabe8863.
Read More
Shuimu's GraFuture CryoEM GO & RGO Grid solving preferential orientation issues

GraFuture™ GO/RGO Support Film

To overcome the bottleneck in cryo-EM sample preparation, Shuimu developed a series of graphene coated grids - GraFuture™, using them to achieve a better reproducibility and efficiency of cryo-EM sample preparation.

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See Unseeable.
Drug Undruggable.

Founded in 2017, Shuimu BioSciences aims to bring the power of cryo-EM to innovative therapeutics developers.

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